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. 2012 Nov 8;34(2):464–474. doi: 10.1093/carcin/bgs353

Fig. 6.

Fig. 6.

Maternal BB exposure lowers body weight and suppresses serum insulin levels in Wnt1-Tg offspring. (A) Body weights of Wnt1-Tg mice enrolled in the tumor study were recorded monthly from weaning (PND21) until study conclusion (up to 8 months). *P < 0.05 relative to CAS. (B and C) The ratio of serum leptin to adiponectin levels and serum insulin levels, respectively, were measured for tumor-bearing Wnt1-Tg mice at killing as described in Materials and methods (n = 9 per diet group). (D) Correlation between serum insulin and tumor weight (normalized to body weight) in Wnt1-Tg tumored mice exposed to CAS (circle) or BB (triangle) via maternal diet. The Pearson correlation coefficient is 0.46; P = 0.05. (E) Body weights and (F) serum insulin levels for mice fed CAS or BB diets beginning at weaning until killing. *P < 0.05 relative to CAS.