Table 3.
Group | Volume D0 (mm3) | Volume D2 (mm3) | Volume D4 (mm3) | Volume D6 (mm3) | Volume D8 (mm3) |
---|---|---|---|---|---|
SP (GBC-SD) | |||||
Con | 0.101±0.011 | 0.139±0.013 | 0.199±0.022 | 0.277±0.021 | 0.379±0.025 |
CDDP | 0.101±0.012 | 0.123±0.012 | 0.174±0.021 | 0.212±0.02 | 0.301±0.049 |
Emodin | 0.102±0.074 | 0.108±0.098 | 0.142±0.015a | 0.183±0.029a | 0.258±0.036a |
CDDP+emodin | 0.103±0.01 | 0.092±0.011a | 0.084±0.01a | 0.078±0.011a | 0.074±0.009a |
Non-SP (GBC-SD) | |||||
Con | 0.102±0.008 | 0.121±0.017 | 0.17±0.025 | 0.232±0.037 | 0.312±0.04 |
CDDP | 0.102±0.008 | 0.103±0.008a | 0.136±0.028a | 0.181±0.022a | 0.25±0.028a |
Emodin | 0.102±0.01 | 0.12±0.019 | 0.169±0.014 | 0.221±0.017 | 0.309±0.027 |
CDDP+emodin | 0.1±0.007 | 0.093±0.002a | 0.084±0.005a | 0.074±0.005a | 0.07±0.005a |
P<0.05, experimental group compared with the control group.
Emodin sensitizes SP and non-SP cells of GBC-SD to CDDP cytotoxicity in xenograft tumors. D, day; (n=6).