Author response image 1. FK506 delivered by DCs protects from systemic immunosuppression.

CD4+ splenocytes from an untreated mouse were cultured with serum drawn from the indicated groups of mice after last dose of either treatment regimen, and the CD4+ T cells were then stimulated for 4 hours with CD3/28 beads. Data are mean fold induction of IL2 mRNA of stimulated vs unstimulated groups + SD. N = 6–10 mice per group. P value was calculated using two-tailed unpaired t-test. Data are representative of two independent experiments.