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. 2013 Feb 1;24(3):308–318. doi: 10.1091/mbc.E12-02-0163

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© 2013 Kang et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Depleting endocytic machinery phenocopies lrp-1(lf) molting defects. Wild-type C. elegans animals (A) fail to molt when fed chc-1 RNAi (B), similar to lrp-1(ku156) animals (C). lrp-1(ku156) molting defects and animal viability are rescued with an lrp-1::gfp transgene (eqIs1, D). LRP-1::GFP can be detected along the anterior-posterior axis within hyp7 (E). Arrowheads indicate unshed cuticle of animals exhibiting molting defects. Scale bar: 20 μm.