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. 2012 Feb 15;32(7):2398–2409. doi: 10.1523/JNEUROSCI.6056-11.2012

Figure 3.

Figure 3.

Restoring D2 receptor expression to normal levels in adult mice reverses the changes in excitability and dendritic morphology. a, Box plots (bars, min/max values; box, lower/upper quartile; line, median) showing RMP, input resistance and rheobase of striatopallidal MSNs in 3-month-old control and D2R-OE mice in normal condition (Tg-On) or after treatment with doxycycline (Tg-Off). **p < 0.01, ***p < 0.001, ****p < 0.0001. b, c, Current–voltage (b) and input–output (c) curves in 3-month-old D2R-OE mice are significantly different from controls (b, p < 0.0001; c, p < 0.0001) and are reversed when transgenic D2R overexpression is turned off. Tg-On: control, n = 21 (4); D2R-OE, n = 19 (4); Tg-Off: control, n = 21 (7); D2R-OE, n = 24 (5). d, The morphological atrophy observed in 3-month-old D2R-OE mice is reversed after 2 weeks of doxycycline treatment. Control, n = 21 (6); D2R-OE, n = 21 (5). e, Total number of primary dendrites, branch points, branch tips and arbor length in control and D2R-OE mice treated (Tg-Off) or not (Tg-On) with doxycycline. Tg-On: control, n = 36 (6); D2R-OE, n = 26 (6); Tg-Off: control, n = 21 (6); D2R-OE, n = 21 (5). *p < 0.05, **p < 0.01.