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The binding of a collagen peptide (in blue) to the eighth FnI domain of fibronectin shows a common interaction mode for the FnI domain with peptides (PDB entry 3ejh; Erat et al., 2009 ▶). The extension of the three-stranded β-sheet by an extra strand is found in all the FnI structures that have been cocrystallized. Such an extension could also be the interaction mode of the FnI domains with amyloid/cross-β structures.
