Table 3. p97 co-factors involved in mammalian dislocation.
Protein | Function | Interaction Domain |
---|---|---|
UFD1/NPL4 [12] | Facilitates engagement of poly-ubiquitin proteins | UBX |
UBXD2 (Erasin) [43] | p97 recruitment | UBX |
UBXD8 [45] | p97 recruitment | UBX |
YOD1 [13] | De-ubiquitylating activity at p97 | UBX |
VIMP [42] | Recruits p97 to the ER membrane | Unknown |
Peptide: N-glycosidase [100] | Enzymatic removal of N-linked glycans | PUB |
Ataxin3 [15] | De-ubiquitylating activity at p97 | VCP binding motif (VBM) |
SAKS1 [50] | Mediates ubiquitin interactions | UBX |