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(A) The increase in luciferase signal is specific to KL promoter activation. (B) Time course of KL promoter activation in HEK293 cells stably transfected with a KL promoter-luciferase construct. q-PCR analysis of KL expression induced by the compounds in (C) primary hippocampal neurons and (D) in primary astrocytes.
KL: Klotho.
