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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Future Med Chem. 2012 Sep;4(13):1671–1679. doi: 10.4155/fmc.12.134

Figure 3. Concentrated endogenously secreted Klotho and compounds 21 and 25 rescue co-cultures of oligodendrocyte precursor cells and astrocytes from TNF-α-induced cytotoxicity.

Figure 3

Cells were pretreated with compounds for 24 h or with concentrated Klotho for 4 h and then exposed to 50 or 100 ng/ml of TNF-α for an additional 24 h. Cell cytotoxicity was assessed by CellTiter-Glo® (Promega).