. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: Future Med Chem. 2012 Sep;4(13):1671–1679. doi: 10.4155/fmc.12.134

Table 1.

Pleiotropic functions of secreted Klotho protein.

Glycoproteins regulated by secreted Klotho	Klotho effects	Ref.
*Ion channels*
Transient receptor potential vanilloid type isoform-5	Increase in Ca²⁺ influx	[25]
*Transporters*
Renal outer medullary potassium channel-1	Increase in K⁺ efflux	[33]
Na-dependent phosphate co-transporter, type-IIa	Decrease in Pi influx	[34]
Pit-1, 2 (Na-dependent phosphate co-transporter, type-III)	Decrease in Pi influx	[35]
*Receptors*
IGF-1 receptors	Inhibition	[15]
TGF-β1 receptor (type-II)	Inhibition	[36]

Modified with permission from [23].