Table 2.

The effect of kit receptor deficiency and ovariectomy on total tibia bone volume and length, cortical bone architecture proximal to the tibio-fibular junction, and cancellous bone volume and architecture in the proximal tibial metaphysis and 3rd lumbar vertebra in 8-week-old mice at 4 weeks following surgery.

	WT		Kit W/W-v		ANOVA (P<)
	Intact	Ovx	Intact	Ovx	Genotype	Surgery	Interaction
Total Tibia
Bone length (mm)	17.10 ± 0.08	17.58 ± 0.10	17.00 ± 0.09	17.37 ± 0.14	NS	0.001	NS
Bone volume (mm3)	14.78 ± 0.42	12.80 ± 0.26	13.23 ± 0.29	12.51 ± 0.29	0.01	0.001	NS
Tibial Diaphysis (cortical bone)
Tissue volume (mm3)	0.154 ± 0.004	0.156 ± 0.002	0.140 ± 0.002	0.138 ± 0.002	0.001	NS	NS
Cortical volume (mm3)	0.118 ± 0.002	0.114 ± 0.002	0.110 ± 0.002	0.102 ± 0.002	0.001	0.01	NS
Marrow volume (mm3)	0.036 ± 0.002	0.042 ± 0.002	0.030 ± 0.002	0.036 ± 0.002	0.001	0.001	NS
Cortical thickness (μm)	260 ± 5	245 ± 2	259 ± 4	235 ± 6	NS	0.001	NS
Proximal Tibial Metaphysis (cancellous bone)
Bone volume/Tissue volume (%)	6.75 ± 0.35	1.99 ± 0.21	6.74 ± 1.28	1.94 ± 0.30	NS	0.001	NS
Connectivity density (1/mm3)	50.62 ± 7.40	6.48 ± 1.29	43.66 ± 15.85	5.05 ± 1.31	NS	0.001	NS
Trabecular number (1/mm)	3.69 ± 0.07	2.87 ± 0.13	3.93± 0.32	2.68 ± 0.10	NS	0.001	NS
Trabecular thickness (μm)	40 ± 1	35 ± 2	37 ± 2	30 ± 2	0.04	0.001	NS
Trabecular spacing (μm)	276 ± 6	366 ± 16	263 ± 18	380 ± 16	NS	0.001	NS
3rd Lumbar Vertebra (cancellous bone)
Bone volume/Tissue volume (%)	12.36 ± 0.74	8.20 ± 0.31	13.68 ± 0.43	8.93 ± 0.42	0.05	0.001	NS
Connectivity density (1/mm3)	156.70 ± 13.90	90.73 ± 5.91	147.63 ± 7.70	90.82 ± 7.01	NS	0.001	NS
Trabecular number (1/mm)	4.47 ± 0.18	3.92 ± 0.06	4.37 ± 0.08	3.68 ± 0.06	NS	0.001	NS
Trabecular thickness (μm)	40 ± 1	36 ± 0	44 ± 1	38 ± 1	0.001	0.001	NS
Trabecular spacing (μm)	228 ± 9	259 ± 4	235 ± 4	277 ± 4	0.04	0.001	NS

Data are mean ± SE