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. 2013 Feb 5;8(2):e55532. doi: 10.1371/journal.pone.0055532

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© 2013 Liu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Effect of miR-130a/301a/454 on tumorigenicity in a nude mouse xenograft model. Control RNA, miR-130a/301a/454 mimic or miR-130a/301a/454 inhibitor-transfected colon cancer HCT116 cells (A, B, C) and SW480 cells (D, E, F) were injected subcutaneously into either side of the posterior flank of the same nude mice, respectively (n = 8 per group). The tumor growth curve is displayed as indicated. *, p<0.05. (G, H) Tumor tissues were collected from two mice in each group at the indicated times, and the levels of expression of miR-130a/301a/454 were examined by qRT-PCR assays.