Table 4. Association of AML1/ETO and IL-23R Variants in M2 AML, and Association of PML/RARα and IL-23R Variants in M3 AML.
Classification | Molecularsubtype | rs1884444 | rs6682925 | ||||||||||
Case | Control | OR(95%CI)a | P b | Case | Control | OR(95%CI)a | P b | ||||||
TT | TG/GG | TT | TG/GG | TT | TC/CC | TT | TC/CC | ||||||
M2 | AML1/ETO | 20 | 25 | 519 | 618 | 1.04(0.59, 1.83) | 0.709 | 14 | 29 | 452 | 665 | 1.21(0.67, 2.20) | 0.929 |
No commonfusion generanscripts | 51 | 55 | 519 | 618 | 0.91(0.60, 1.37) | 35 | 66 | 452 | 665 | 1.17(0.76, 1.81) | |||
Unknown & Others | 8 | 14 | 519 | 618 | – | 7 | 14 | 452 | 665 | – | |||
M3 | PML/RARα | 26 | 49 | 519 | 618 | 1.51(0.87, 2.62) | 0.241 | 23 | 50 | 452 | 665 | 1.33(0.75, 2.37) | 0.511 |
No commonfusion generanscripts | 5 | 4 | 519 | 618 | 0.64(0.17, 2.41) | 4 | 5 | 452 | 665 | 0.82(0.22, 3.10) | |||
Unknown & Others | 3 | 1 | 519 | 618 | – | 3 | 1 | 452 | 665 | – |
Adjusted for age and gender;
P value for heterogeneity test based on χ2-based Q test.