Table 2. Membrane properties of CA1 pyramidal neurons in control or clodronate- or MIF-treated organotypic slices at DIV6 and 14.

	DIV6			DIV14
Parameter	Control	Clodronate	MIF	Control	Clodronate	MIF
RMP (mV)	−67.7±1.2	−71.0±0.8*	−67.00±1.7	−63.7±0.7	−64.9±1.1	−63.7±1.6
Cm (pF)	15.3±0.7	17.4±1.4	18.0±1.8	16.4±1.3	15.6±1.5	16.1±2.8
Rm (mΩ)	243±33	212±36	186±20	188±7	169±14	171±13
Tau (ms)	3.5±0.4	3.4±0.5	3.1±0.2	3.0±0.2	2.6±0.2	2.6±0.3
Rheobase (pA)	100±5	112±8	132±8*	133±7	139±19	111±8*
Time to the first AP (ms)	438±48	531±49	525±73	561±41	312±49*	424±97
AP peak (mV)	35.6±2.0	33.0±1.8	29.0±3.6	38.8±1.7	22.0±4.0	37.1±2.7
Threshold (mV)	−44.6±0.8	−44.2±1.0	−40.3±2.2	−34.0±1.5	−38.2±3.0	−36.7±1.5
AP half-width (ms)	1.8±0.1	1.5±0.1	1.8±0.2	2.4±0.1	1.9±0.1	1.9±0.1
AHP peak (mV)	−9.2±0.5	−8.2±0.9	−10.3±1.9	−11.2±1.0	−13.1±1.9	−10.1±1.0
n	28	24	10	23	9	5

Values shown are mean ± SEM.

^*, Statistically significant differences at p<0.05 when compared with the respective control at DIV6 or 14.

RMP, resting membrane potential; Cm, membrane capacitance; Rm, membrane resistance; AP, action potential; AHP, afterhyperpolarization.