Table 3. Membrane properties of hippocampal pyramidal neurons in co-cultures with or without microglia.
| Parameter | Neurons only | Neurons+microglia |
| RMP (mV) | −70.3±1.6 | −73.4±2.0 |
| Cm (pF) | 19.8±1.5 | 17.0±0.9 |
| Rm (mΩ) | 344±24 | 336±33 |
| Tau (ms) | 6.1±0.8 | 6.0±0.6 |
| Rheobase (pA) | 232±22 | 311±32* |
| Time to the first AP (ms) | 692±62 | 341±88* |
| AP peak (mV) | 28.6±1.4 | 26.5±2.8 |
| Threshold (mV) | −28.5±1.8 | −21.5±2.2 |
| AP half-width (ms) | 2.0±0.1 | 1.9±0.2 |
| AHP peak (mV) | −21.8±0.9 | −23.5±2.0 |
| n | 27 | 15 |
All values are means ± SEM.
*
, Statistically significant differences at p<0.05 when compared with neurons only.
RMP, resting membrane potential; Cm, membrane capacitance; Rm, membrane resistance; AP, action potential; AHP, afterhyperpolarization.