Table 2. Summary of the coefficients used for IV ratio analyses.
| IV | Allele Score with the Intermediate Trait | Allele Score with the Outcome | IV Ratioa | |
| Coefficient, % (95% CI) | Coefficient,% (95% CI) | Coefficient (95% CI) | p-Value | |
| BMI risk score | 0.14 (0.12–0.16) | −0.06 (−0.1 to −0.02) | −0.42 (−0.71 to −0.13) | 0.005 |
| Synthesis score | −3.47 (−3.90 to −3.05) | 0.01 (−0.17 to 0.20) | −0.00 (−0.06 to 0.05) | 0.88 |
| Metabolism score | −5.38 (−5.84 to −4.93) | 0.17 (−0.02 to 0.35) | −0.03 (−0.06 to 0.01) | 0.08 |
a
Calculated as the ratio between the allele score association with the outcome and intermediate trait. Coefficients can be interpreted as percent change in the outcome by percent change in the intermediate trait.