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. 2013 Feb 5;10(2):e1001383. doi: 10.1371/journal.pmed.1001383

Table 3. Results for the association between vitamin D SNPs/allele scores and BMI from the GIANT consortium.

SNPs/Allele Scores Gene Symbol Per Allele Change in BMI, kg/m2 (95% CI) p-Value
rs12785878 DHCR7 0.001 (−0.01 to 0.009) 0.78
rs10741657 CYP2R1 −0.005 (−0.004 to 0.01) 0.30
Synthesis allele score (rs12785878+rs10741657) DHCR7 + CYP2R1 −0.002 (−0.009 to 0.005)a 0.57
rs2282679 GC 0.001 (−0.011 to 0.010) 0.91
rs6013897 CYP24A1 0.003 (−0.008 to 0.014) 0.61
Metabolism allele score (rs2282679+rs6013897) GC + CYP24A1 0.002 (−0.006 to 0.009)a 0.67

The GIANT meta-analyses consisted of 46 studies with up to 123,865 adults of European ancestry [23], including the 1958 British Birth Cohort, Framingham Heart study, Nurses' Health Study, Twins UK, UK Blood Services Common Control Collection, the Amish Family Osteoporosis Study, Health2000 GENMETS sub-sample, and Northern Finland Birth Cohort 1966, which were also part of the D-CarDia collaboration.

a

Calculated as described in Ehret et al. [35].