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The influence of antagonists of thrombin receptors in brazilin-mediated platelet aggregation. Washed platelets (3.6 × 108/ml) were preincubated with SCH79797 (1 μM) or tcY-NH2 (100 μM); this was followed by the addition of (A) thrombin (0.5 U/ml), (B) collagen (1 μg/ml), or (C) brazilin (50 μM) to trigger platelet aggregation. Aggregation profiles (A to C) are representative examples of 4 similar experiments.
