Table 1.

Macrocyclic lactones and dosages licensed in different formulations for the prevention of infestations caused by Dirofilaria immitis (Di) or Dirofilaria repens (Dr) in dogs

Macrociclic lactone	Formulation	Dosage	Claim
Ivermectin	Tablets/Chewables	6 mcg/kg	Di, Dr
Ivermectin/Praziquantel	Chewables	6 mcg/kg / 5 mg/kg	Di, Dr
Milbemycin oxime*	Tablets	0.5 mg/kg	Di
Moxidectin	Tablets	3 mcg/kg	Di
	Injectable	0.17 mcg/kg	Di, Dr
Moxidectin/Imidacloprid	Spot on	2.5 mg/Kg / 10 mg/kg	Di
Selamectin	Spot on	6 mg/kg	Di

*Tablets containing either praziquantel or lufenuron are also available for chemoprevention at the same dosage (modified from [66]).