Figure 2. Oral glucose tolerance test and insulin levels after chronic CB receptor agonist treatment or LPS treatment.

(A) Plasma glucose profile subsequent to a 2 g/kg glucose oral challenge in freely mobile mice. Two-way ANOVA followed by the Bonferroni post hoc analysis revealed the time (p<0.0001), treatment (p = 0.195) and interaction (p = 0.046) effects. * indicates a significant difference (p<0.05) versus CT, as determined by a two-way ANOVA followed by the Bonferroni post hoc test. (B) Plasma insulin levels at 30 min before glucose loading and 15 min after glucose loading. All results are expressed as the means±SEM for 7–9 mice per group from the HU-treated group (HU) and the LPS-treated group (LPS) compared with the plasma insulin levels of the control group (CT).