Table 1. QTLs for glomerular injury score in postmenopausal F2 (Dahl S x R) intercross female rats.
QTL | Model | Rat-location | LOD | % |
GIS-pm1 | Recessive | Chr4: 74–112 Mbp | 3.54 (HS) | 12 (↓) |
GIS-pm2 | Dominant | Chr3: 80–120 Mbp | 2.72 (S) | 9 (↑) |
GIS-pm3 | Dominant | Chr5: 125–145 Mbp | 2.37 (S) | 8 (↑) |
GIS-pm4 | Dominant | Chr2: 215–235 Mbp | 1.70 (Sug) | 6 (↓) |
GIS-pm5 | Recessive | Chr7: 15–35 Mbp | 1.28 (Sug) | 5 (↓) |
QTL, quantitative trait locus; GIS, glomerular injury score; Chr, chromosome; % , the amount in % of total trait variance that would be explained by a QTL at these loci; Mbp, mega-base pair; LOD, logarithm of the odds score derived from the likelihood ratio statistic using a factor of 4.6; ↑, S-allele increases trait; ↓, S-allele decreases trait. Significance determined from 2000 permutations on data set: LOD 3.17 highly significant (HS); LOD 2.17 significant (S); LOD 1.15 suggestive (Sug).