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. 2013 Feb 5;8(2):e56046. doi: 10.1371/journal.pone.0056046

Figure 2. Both short and long-term febuxostat treatment lowered uric acid and increased hypoxanthine circulating and tissue levels in DOCA-salt rats.

Figure 2

HPLC measurements of uric acid (A, C) and hypoxanthine (B, D) in DOCA-salt rats after short (A, B) or long (C, D)-term febuxostat administration. Data are expressed as means ± SEM for N = 6–8. *represents a statistically significant difference (p<0.05) between febuxostat and control rats.