Fig. 1.
Brain expression relative quantification (RQ) values from quantitative real-time polymerase chain reaction relative to GAPDH as an endogenous control. Data are presented as RQ expression values, which represent 2−ΔΔ-Ct metrics. The groups compared are bipolar disorder (BD), major depressive disorder (MDD) and non-psychiatric controls (Con) using analysis of variance (ANOVA) analyses followed by Tukey’s post tests. (a) Relative quantitative expression for variant SYN1a (ANOVA p=0.0045 ; after outlier analysis BD n=13, MDD n=15, Con n=11). (b) Relative quantitative expression for variant SYN1b (ANOVA p=0.0172 ; after outlier analysis BD n=13, MDD n=15, Con n=11). (c) Relative quantitative expression for variant SYN2a (ANOVA p=0.0001 ; after outlier analysis BD n=13, MDD n=12, Con n=13). (d) Relative quantitative expression for variant SYN2b (ANOVA p=0.0005 ; after outlier analysis BD n=13, MDD n=15, Con n=11). (e) Relative quantitative expression for variant SYN3a (ANOVA p=0.2121 ; after outlier analysis BD n=12, MDD n=12, Con n=12). (f) Relative quantitative expression for variant SYN3g (ANOVA p=0.1551 ; after outlier analysis BD n=12, MDD n=14, Con n=12).