Table 3.

Histone 3 lysine 4 tri-methylation (H3K4me3) enrichment results

	BD vs. Con	MDD vs. Con	BD vs. MDD
SYN1 a+b
ANOVA p value	0.005**
Tukey’s multiple comparison test (q)	0.4217	4.046	4.211
Significance	n.s.	*	*
SYN2 a+b
ANOVA p value	0.0187*
Tukey’s multiple comparison test (q)	4.267	2.366	1.501
Significance	*	n.s.	n.s.

For each of the four different synapsin promoter regions, chromatin immunoprecipitation (ChIP) or input enrichment was quantified using quantitative real-time polymerase chain reaction.

We report ChIP: input ratios of relative quantification expression values, which represent 2^−ΔΔ-Ct metrics.

One-way analyses of variance (ANOVA) and Tukey’s post-hoc tests were computed for the three diagnostic groups: bipolar disorder (BD), control (Con) and major depressive disorder (MDD).

p Values are presented along with significance levels (* p≤0.05 ; ** p≤0.001 ; ** p≤0.0001).