Table 2.
Reported estimated glomerular filtration rates (eGFR) before, 1 year after, and at the end of study following HCT.
| Author | Study Years | Type+ | Age++ | Pretransplant* eGFR | 1 Year eGFR | Final** eGFR | ΔeGFR |
|---|---|---|---|---|---|---|---|
| Weiss4 | 1998–2002 | Allo | A | 80.0 (29.2) | 81.9 (29.4) | 81.9 (29.4) | 1.9 |
| Delgado^^28 | 1996–2004 | Allo | A | 103.3 (38.0) | 51.2 (27.0) | 31.3 (17.1) | −72 |
| Parikh36 | 1995–2000 | Allo | A | 106 (29.5) | 52 (25) | 52 (25) | −54.0 |
| Kist-van Holthe^^13 | 1998–2000 | Allo | P | 116 (…) | 98 (…) | 104 (…) | −12 |
| Kist-van Holthe^^13 | 1991–1998 | Allo | P | 118 (…) | 97 (…) | 97 (…) | −21 |
| Lonnerholm21 | 1985–1990 | Auto | A | 94 (25) | 85 (21) | 82 (25) | −12 |
| Frisk20 | 1985–1997 | Auto | P | 125.8 (…) | … | 107 (…) | −18.8 |
| Lonnerholm21 | 1985–1990 | Auto | P | 114 (21) | 103 (29) | 103 (16) | −11 |
| Carlson37 | 1987–1991 | Auto | P/A | 92.7 (…) | … | 58.1 (…) | −34.6 |
| Miralbell^^35 | 1994–1997 | Both | A | 102 (24) | 73 | 77 (22) | −25 |
| LeBlond34 | 1985–1991 | Both | A | 107 (4) | … | 92 (3) | −15 |
| Patzer40 | 1992–1998 | Both | P/A | 130 (…) | 123 (…) | 105 (…) | −25 |
| Hingorani^^30 | 1991–2002 | Both | P/A | 100 (…) | 79.6 (…) | 79.6 (…) | −20.4 |
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| Weighted Averages | 101.9 | 78.7 | 77.4 | −24.5 | |||
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Studies that included data on eGFR are reported here. Many studies did not actually present eGFR data and are not shown here (3,9,12,24,25,26,27,29,31,32,33,38,41,42). Weighted averages appear at the bottom of the table. The table is organized by transplant type, then age of the HCT recipients. SCr = serum creatinine (mg/dL); ΔeGFR = glomerular filtration rate (mL/min/1.73m2); () = standard deviation;
= mean final study follow up measurement;
= mean pre transplant measurement;
= updated data came from personal communication with author of study;
= Type of transplants performed in study: Allo = data from only allogeneic recipients; auto = data from only autologous recipients; both = data from both allogeneic and autologous transplant recipients.
= Age of transplant recipients: A = adults (greater than 18 years old); P = pediatrics (less than 18 years old); P/A: patients from all age groups included; … = data not available; Δ = post transplant minus pre transplant measurement; Final eGFR was a measurement taken between 18 and 36 months after HCT.