. Author manuscript; available in PMC: 2014 Jan 22.

Published in final edited form as: Biochemistry. 2013 Jan 10;52(3):447–455. doi: 10.1021/bi301066z

Table 3.

CO association/dissociation rates and equilibrium constants

Heme Protein	location	k_{+co, pent} (mM⁻¹s⁻¹)	k_−co (s⁻¹)	K_{d, CO, pent} (μM)	K_d,co (μM)	K_A,his
HP7H7F	Loop end	220 ± 6^c	0.0667 ± 0.0002^c	0.303 ± 0.009^c	9 ± 2	29 ± 5^b
CC9H7F	Open end	296 ± 9^c	0.023 ± 0.005^c	0.08 ± 0.02^c	30 ± 10	380 ± 60^b
HP7	Open end	950^a	0.034^a	0.036^a	0.68^a	18^a

Data from reference 3

Data from reference 6

This work