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. Author manuscript; available in PMC: 2013 Feb 5.
Published in final edited form as: Integr Biol (Camb). 2011 Aug 15;3(9):910–921. doi: 10.1039/c1ib00043h

Fig. 2.

Fig. 2

In situ biomechanical characterization reveals mechanical stiffening and heterogeneity of the tumor epithelium. (A) Representative fluorescence microscopy images showing mammary gland epithelium (green) tagged in the ACTB-ECFP transgenic mouse. AFM indentations were performed in 90 × 90 μm areas (white squares) and the measurements obtained within this area are represented as a force heat map. Scale bar = 100 μm. (B) Bar graph representing the Young’s elastic modulus obtained by AFM indentation of in situ epithelium (left) or ex vivo cultured epithelium (right). Error bars represent average ± S.E.M. *P < 0.05. Graphs represent compiled measurements taken from at least 8 mice. Each force map is made up of 36 indentations.