Table 1.
Clinical and laboratory characteristics of HIV-positive and HIV-negative septic patients admitted to study
| Characteristic | HIV-positive (n=36) | HIV-negative (n=22) | P* |
|---|---|---|---|
| Age – mean years±SD | 39.5±9.8 | 46.3±18.0 | 0.07 |
| Sex, n (%) | 0.09 | ||
| Male | 24 (66.7) | 10 (45.5) | |
| Female | 12 (33.3) | 12 (54.5) | |
| Sepsis severity | |||
| Severe sepsis (%) | 44.4 | 45.5 | 0.58 |
| Septic shock (%) | 55.6 | 54.5 | 0.58 |
| Prognostic scores | |||
| APACHE II | 21.5±7.9 | 22.3±6.2 | 0.67 |
| SOFA | 8.8±4.6 | 7.8±3.1 | 0.37 |
| Number of organic dysfunctions | 4 (2–5) | 3 (2–5) | 0.83 |
| Suspected focus of infection (%) | 0.001 | ||
| Pulmonary | 83.3 | 40.9 | |
| Central nervous system | 1.8 | 17.8 | |
| Bloodstream | 5.6 | 13.6 | |
| Urinary | 0.0 | 13.6 | |
| Dermatologic | 0.0 | 12.3 | |
| Abdominal | 8.3 | 0.0 | |
| Etiologic agent (%) | 0.001 | ||
| Bacteria | |||
| Gram– rods | 8.3 | 36.4 | |
| Gram+ cocci | 27.8 | 36.4 | |
| Fungi | 44.4 | 9.1 | |
| Mycobacteria | 16.7 | 0.0 | |
| Unknown | 2.8 | 18.2 | |
| Mechanical ventilation on first day (%) | 58.3 | 63.6 | 0.52 |
| Vasopressors on first day (%) | 61.1 | 54.5 | 0.41 |
| Lactate (mmol/L) | 2.9±1.3 | 2.8±1.4 | 0.84 |
| Glucose (mg/dl) | 125.5±75.5 | 135.2±57.9 | 0.61 |
| Cortisol (µg/dL) median (25–75 IQR) | 17.9 (10.3–55.7) | 16.7 (6.3–36.2) | 0.95 |
| WBC (cell/mm3) median (25–75 IQR) | 5,555 (3,010–12,000) | 19,630 (13,140–25,950) | 0.02 |
| Time from organic dysfunction onset (hours) | 15 (8.5–24.0) | 18 (8.0–24.0) | 0.50 |
| Length of hospital stay before ICU admission (hours) | 18.0 (16.0–24.0) | 15.0 (4.0–24.0) | 0.60 |
*
Wilcoxon–Mann–Whitney test; student t-test; Chi-square test; Fisher's exact test.