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AON-mediated skipping of IL-1RAcP exon 9. Targeting exon 9 in IL-1RAcP pre-mRNA with AON (black bar) induces the expression of an alternatively spiced mRNA encoding a soluble isoform (Δ9IL-1RAcP) that lacks the transmembrane domain. AON, antisense oligonucleotide; IL-1RAcP, interleukin-1 receptor accessory protein.
