Table 2. Data summary for TRPV4 antagonists ^(a).

Antagonist	Potency (IC50, μM)	Species	Cross-reactivity
RN-1734	2.3 5.9 3.2	human mouse rat	---
RN-9893	<0.12 <0.06 <0.12	human mouse rat	---
HC-067047	0.048 0.017 0.133	human mouse rat	inhibits TRPM8, HERG at submicromolar
Ruthenium Red	<0.086-1 <0.21-1 <0.2-0.33	human mouse rat	inhibits all TRPVs, TRPM6, TRPM8, TRPA1, RyR1-3
Capsazepine	18.6 13.5	human rat	Inhibits TRPV1, TRPM8
Citral	32	mouse	Inhibits TRPA1, activates TRPV1, TRPV3, TRPM8

^(a)modified from ^{89, 90}