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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Nov 2;65(1):49–59. doi: 10.1016/j.addr.2012.10.014

Figure 3.

Figure 3

Desing of a RAFT chain transfer agent that contains two active sites connected via an enzyme sensitive sequence (Peptide2CTA) permits the synthesis of a biodegradable diblock copolymer in one step. (A) Polymerization of HPMA in methanol mediated by Peptide2CTA and 2,2’azobisisobutyronitrile (AIBN). [HPMA]0/[CTA]0 = 2000, [HPMA]0 = 1 M; [CTA]0/[AIBN]0 = 2.5. (B) Following incubation of the polyHPMA with papain, the molecular weight decreased to half of the original polymer, indicating that the monomers inserted with equal efficacy at both dithiobenzoate sites. Adapted from [156].