Table 1.

IBD/PSC diagnosis criteria and evidence of resolution during OV for 9 patients

			IBD/PSC Diagnosis Criteria		Evidence of Resolution post OV
Subject	Sex	Age	Intestinal	Liver	Intestinal	Liver
01	M	10y	Acute chronic colitis of colon	Chronic hepatitis (grade 2–3) with stage 2 fibrosis	No significant abnormality in intestinal biopsies; resolution of symptoms associated with IBD	Normal bile ducts; no evidence of inflammation; normalization of LFTs
02	M	16y	Acute chronic colitis and cryptitis of the cecum, transverse and descending colon with quiescent colitis in sigmoid colon and rectum	Patchy portal tract fibrosis; cholangiolar proliferation; stage III fibrosis	Normal sigmoid, decscending, and transverse colon with good vascularity; minimal inflammation in cecum	Much less inflammation and fibrosis; preservation of portal tracts and overall architecture – stage II fibrosis
03	M	3y	Colonic colitis on biopsy	Biliary tract outflow obstruction; chronic active inflammation of portal biliary tree	Asymptomatic for IBD and elimination of positive IBD serology.	No significant abnormality on biopsy – normal biliary tree and liver parenchyma and no evidence of PSC
04	M	7y	Moderate acute and chronic inflammation with cryptitis throughout colon and rectum	Bile ductular proliferation; focal bridging fibrosis	Colonic tissues show no significant abnormality; asymptomatic for IBD	Minimal portal inflammation without any other visible abnormalities
05	F	2y	Focal acute cryptitis throughout colon	Biliary cirrhosis with prominent cholangiolar and bile ductular proliferation; bridging fibrosis	Improvement in histologic features compared to previous biopsies; asymptomatic for IBD	Improved fibrosis but not cirrhosis. Reduced FIBROSpect score from 98 to 61.
06	M	13y	Diffuse chronic and focal acute inflammation of colonic tissue; erythemea and pus in rectal and colonic tissues	Multifocal narrowing and beading of right and left hepatic ducts and branches with biliary strictures; hepatic parenchymal inflammation	No blood/mucus in stools and no abnormality in frequency of stools; no abdominal pain; asymptomatic for IBD	Resolution of biliary strictures; normal liver parenchyma
07	F	6y	Evidence of chronic active colitis. Lamina propria expanded and occupied by lymphoplasmacytic infiltrate. Well developed crypt abscesses	Portal and periportal fibrosis. Portal areas expanded by significant inflammatory infiltrates	No diagnostic abnormalities in histological findings	Virtually no inflammation, fibrosis involving portal regions much reduced
08	M	15y	Evidence of active colitis in all large bowel biopsies, including rectum. Also evidence of active inflammation with neutrophil infiltrate and small areas of cryptitis	Mild fibrosis and lymphoplasmacytic infiltrate in portal tracts	No evidence of significant abnormality in any biopsies	Liver appears essentially unremarkable. No longer portal fibrosis or inflammation
09	F	9y	Crypt architectural distortion and increased lymphoplasmacytic inflammation; consistent with chronic IBD	Portal tracts with mixed inflammatory infiltrate composed predominantly of lymphocytes, also with neutrophils around ductules and in ducts. Evidence of periportal expansion/fibrosis	Marked improvement compared to prior biopsies. Only focal, minimal acute inflammatory changes noted	Portal tracts appear overall normal. No significant inflammation