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. 2012 Oct 25;36(2):177–182. doi: 10.1038/hr.2012.160

Table 3. End points of the HONEST Study.

Primary end point
Time from start of treatment to first occurrence of major cardiovascular (CV) events defined as cerebral infarction, intracerebral hemorrhage, subarachnoid hemorrhage, stroke of unknown type, myocardial infarction, coronary revascularization procedures for angina pectoris or sudden death.
 
Secondary end points
1) Time from start of treatment to first occurrence of major event including major CV events, hospital admission for angina pectoris or heart failure, aortic dissection, arteriosclerosis obliterans, end-stage renal disease, doubling of serum creatinine concentration and death from any cause.
2) Change in home and clinic blood pressure levels.
3) Safety.