| (1) Stroke |
| ‘Stroke' is recorded if patients have classic neurologic symptoms for ⩾24 h and their computed tomographic and magnetic resonance imaging findings are consistent with clinical types of stroke. Stroke is classified as cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage or unclassified stroke. Cerebral infarction is subclassified as atherothrombotic cerebral infarction, cardiogenic cerebral infarction, lacunar infarction and unclassified cerebral infarction depending on Trial of Org 10172 in Acute Stroke Treatment classification.23
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| Death within 28 days of the onset of stroke is recorded as fatal stroke; all other cases are non-fatal stroke. |
| (2) Myocardial infarction |
| ‘Myocardial infarction' is recorded based on overall judgment of the presence of symptoms of possible acute myocardial infarction, as well as specific findings from biochemical tests, electrocardiography, and so on. Death within 28 days of the onset of myocardial infarction is recorded as fatal myocardial infarction; other cases are non-fatal myocardial infarction. |
| (3) Coronary revascularization for angina pectoris |
| ‘Coronary revascularization for angina pectoris' is recorded when coronary revascularization (for example, percutaneous coronary intervention, coronary artery bypass graft) is needed for suspected myocardial infarction or diagnosed angina pectoris. |
| (4) Hospitalization for angina pectoris |
| ‘Hospitalization for angina pectoris' is recorded when patients are admitted to hospital for treatment of angina pectoris, except when coronary revascularization is being done. |
| (5) Hospitalization for heart failure |
| ‘Hospitalization for heart failure' is recorded when patients are admitted to hospital for treatment of heart failure. Heart failure is diagnosed when patients meet ⩾2 major criteria for heart failure in the Framingham Heart Study,24 1 major criteria and ⩾2 minor criteria, or New York Heart Association classification of heart function III or IV. |
| (6) Sudden death ‘Sudden death' is defined as an unexpected death within 24 h of onset, without external causes. |
| (7) Aorta dissection |
| ‘Aorta dissection' is defined as a tear in the aortic intima allowing blood to enter the aortic media, confirmed by computed tomography, echocardiography or magnetic resonance angiography, and so on. |
| (8) Arteriosclerosis obliterans |
| ‘Arteriosclerosis obliterans' is recorded when patients correspond to classes II–IV of the Fontaine classification, have an ankle–brachial index of <0.9 or have sites of obstruction (stenosis) confirmed by echocardiography, magnetic resonance angiography or angiography. |
| (9) End-stage renal disease |
| ‘End-stage renal disease' is recorded when patients have serum creatinine concentration ⩾5.0 mg dl−1 (except for temporary increases), need chronic dialysis or need renal transplantation. |
| (10) Doubling of serum creatinine |
| ‘Doubling of serum creatinine' is defined as persistent doubling of baseline serum creatinine and a serum creatinine ⩾2.0 mg dl−1. |
| (11) All death. |
