Table 2.
Top 10 directly genotyped SNP associations from the case-control analysis of lung cancer in African-Americans
| SNPa | Position | Gene | Alleleb | MAFc | OR (95% CI)d | P-valuee |
|---|---|---|---|---|---|---|
|
| ||||||
| rs2036527 | Chr15:78851615 | 6.3kb upstream of CHRNA5 | C/T | 0.2102 | 1.34(1.17–1.54) | 2.0 × 10−5 |
| rs17486278 | Chr15:78867482 | intron 1 of CHRNA5 | A/C | 0.2802 | 1.31 (1.15–1.48) | 2.7 × 10−5 |
| rs16969968 | Chr15:78882925 | exon 5 of CHRNA5 (missense Asp → Asn) | G/A | 0.06008 | 1.57(1.25–1.97) | 1.1 × 10−4 |
| rs7180002 | Chr15:78873993 | intron 2 of CHRNA5 | A/T | 0.102 | 1.40(1.17–1.68) | 2.1 × 10−4 |
| rs951266 | Chr15:78878541 | intron 2 of CHRNA5 | C/T | 0.1031 | 1.39 (1.16–1.66) | 2.8 × 10−4 |
| rs17486195 | Chr15:78865197 | intron 1 of CHRNA5 | A/G | 0.114 | 1.36 (1.14–1.61) | 5.4 × 10−4 |
| rs4243084 | Chr15:78911672 | intron 1 of CHRNA3 | C/G | 0.1753 | 1.28 (1.11–1.48) | 8.5 × 10−4 |
| rs2735940 | Chr5:1296486 | 1.3kb upstream of TERT | T/C | 0.479 | 0.82 (0.73–0.93) | 1.1× 10−3 |
| rs4635969 | Chr5:1308552 | 13.3kb upstream of TERT | C/T | 0.3328 | 0.81 (0.72–0.92) | 1.2 × 10−3 |
| rs17405217 | Chr15:78731149 | intron 1 of IREB2 | C/T | 0.05842 | 1.43(1.14–1.81) | 2.5× 10−3 |
a
ordered by P-value;
b
minor allele listed second;
c
MAF in controls only;
d
OR for each additional copy of the minor allele, estimated in a logistic regression model adjusted for: age, sex, study site, % sub-Saharan African Ancestry, %European ancestry, and number of pack-years smoked;
e
P-value in an allelic additive logistic regression model, adjusted for: age, sex, study site, % sub-Saharan African Ancestry, %European ancestry, and number of pack-years smoked