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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2012 Dec 5;22(2):251–260. doi: 10.1158/1055-9965.EPI-12-1007-T

Table 2.

Top 10 directly genotyped SNP associations from the case-control analysis of lung cancer in African-Americans

SNPa Position Gene Alleleb MAFc OR (95% CI)d P-valuee

rs2036527 Chr15:78851615 6.3kb upstream of CHRNA5 C/T 0.2102 1.34(1.17–1.54) 2.0 × 10−5
rs17486278 Chr15:78867482 intron 1 of CHRNA5 A/C 0.2802 1.31 (1.15–1.48) 2.7 × 10−5
rs16969968 Chr15:78882925 exon 5 of CHRNA5 (missense Asp → Asn) G/A 0.06008 1.57(1.25–1.97) 1.1 × 10−4
rs7180002 Chr15:78873993 intron 2 of CHRNA5 A/T 0.102 1.40(1.17–1.68) 2.1 × 10−4
rs951266 Chr15:78878541 intron 2 of CHRNA5 C/T 0.1031 1.39 (1.16–1.66) 2.8 × 10−4
rs17486195 Chr15:78865197 intron 1 of CHRNA5 A/G 0.114 1.36 (1.14–1.61) 5.4 × 10−4
rs4243084 Chr15:78911672 intron 1 of CHRNA3 C/G 0.1753 1.28 (1.11–1.48) 8.5 × 10−4
rs2735940 Chr5:1296486 1.3kb upstream of TERT T/C 0.479 0.82 (0.73–0.93) 1.1× 10−3
rs4635969 Chr5:1308552 13.3kb upstream of TERT C/T 0.3328 0.81 (0.72–0.92) 1.2 × 10−3
rs17405217 Chr15:78731149 intron 1 of IREB2 C/T 0.05842 1.43(1.14–1.81) 2.5× 10−3
a

ordered by P-value;

b

minor allele listed second;

c

MAF in controls only;

d

OR for each additional copy of the minor allele, estimated in a logistic regression model adjusted for: age, sex, study site, % sub-Saharan African Ancestry, %European ancestry, and number of pack-years smoked;

e

P-value in an allelic additive logistic regression model, adjusted for: age, sex, study site, % sub-Saharan African Ancestry, %European ancestry, and number of pack-years smoked