Table 3.
Top three directly genotyped SNP associations in each lung cancer histologic subgroupa
| Adenocarcinoma (N=538) | Squamous cell (N=343) | Small cell (N=87) | All histologies (N=1308) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Histologic subtype | SNP | Position | Gene | Alleleb | ORc | P-valued | ORc | P-valued | ORc | P-valued | ORc | P-valued |
| Adenocarcinoma | rs2735940 | Chr5:1296486 | 1.3kb upstream of TERT | T/C | 0.75 | 8.1 × 10−5 | 0.81 | 0.024 | 0.87 | 0.3991 | 0.82 | 1.1× 10−3 |
| rs7725218 | Chr5:1282414 | intron 2 of TERT | G/A | 1.33 | 2.0× 10−4 | 1.08 | 0.43 | 0.91 | 0.5635 | 1.13 | 0.047 | |
| rs2736100 | Chr5:1286516 | intron 1 of TERT | T/G | 1.31 | 2.7 × 10−4 | 1.13 | 0.17 | 1.12 | 0.4955 | 1.17 | 8.9× 10−3 | |
|
| ||||||||||||
| Squamous cell | rs401681 | Chr5:1322087 | intron 13 of CLPTM1L | T/C | 1.12 | 0.12 | 1.35 | 1.5× 10−3 | 1.16 | 0.37 | 1.18 | 4.3 × 10−3 |
| rs2844463 | Chr6:31615167 | intron 7 of BAT3 | C/T | 0.92 | 0.26 | 0.74 | 1.8× 10−3 | 1.0 | 0.99 | 0.91 | 0.13 | |
| rs2736158 | Chr6:31600304 | exon 16 of BAT2 (missense Ala → Gly) | C/G | 1.06 | 0.61 | 0.64 | 1.8× 10−3 | 1.16 | 0.53 | 1.04 | 0.66 | |
a
top three associations for small-cell carcinoma are not included due to limited sample size. All three SNPs were located on 15q25.1
b
minor allele listed second
c
OR for each additional copy of the minor allele, estimated in a logistic regression model adjusted for: age, sex, study site, % sub-Saharan African Ancestry and number of pack-years smoked
d
P-value in an allelic additive logistic regression model, adjusted for: age, sex, study site, % sub-Saharan African Ancestry and number of pack-years smoked