Table 3.
Comparisons of Percentage Change in Radius HRpQCT and DXA Parameters From Baseline to Year 4 Between Participants on Placebo vs E Treatment
| Placebo (n = 31) | Estrogen (n = 45) | P | |
|---|---|---|---|
| Radius HRpQCT | |||
| Cortical vBMD, mg/cm3 | −2.9 ± 0.5 | −0.9 ± .6 | .015 |
| Cortical porosity, % | 29.5 ± 6.1 | 8.9 ± 5.7 | .018 |
| Cortical pore volume, mm3 | 28.8 ± 6.1 | 9.8 ± 5.4 | .025 |
| Cortical area, mm2 | −1.3 ± 1.3 | 0.6 ± 2.1 | .494 |
| Cortical thickness, mm | −0.6 ± 1.9 | 0.5 ± 2.2 | .719 |
| Endocortical circumference, mm | 0.2 ± 1.3 | −0.3 ± 1.2 | .786 |
| Periosteal circumference, mm | 2.1 ± 2.4 | −0.2 ± 0.9 | .313 |
| Trabecular BV/TV | −10.7 ± 1.6 | −6.7 ± 1.4 | .066 |
| Trabecular area, mm2 | 0.3 ± 2.7 | −0.7 ± 2.4 | .783 |
| Trabecular number, 1/mm | −4.1 ± 1.4 | −1.6 ± 1.6 | .248 |
| Trabecular thickness, mm | −6.6 ± 1.5 | −5.2 ± 1.1 | .432 |
| Trabecular separation, mm | 5.4 ± 1.5 | 2.4 ± 1.7 | .207 |
| DXA regional aBMD | |||
| Femoral neck, g/cm2 | −4.5 ± 0.7 | −0.9 ± .8 | .003 |
| Trochantar, g/cm2 | −2.4 ± 1.3 | −0.7 ± 1.1 | .318 |
| Diaphysis, g/cm2 | −3.8 ± 0.7 | −1.0 ± 0.8 | .015 |
| Total hip, g/cm2 | −3.4 ± 0.8 | −0.5 ± 0.8 | .020 |
| Lumbar spine L1–L4, g/cm2 | −3.7 ± 0.9 | 3.6 ± 0.7 | <.001 |
| Ultradistal radius, g/cm2 | −5.8 ± 1.2 | −0.7 ± 0.9 | <.001 |
| Total radius, g/cm2 | −4.3 ± 0.8 | −0.5 ± 0.5 | <.001 |
Values are presented as mean ± SE.