Table 4.

Ten-year incidence of CHD, HF, and CV mortality by thyroid status defined by TSH measurements at 1992–1993 and 1994–1995 visits

	Euthyroid	Persistent subclinical hypothyroid	Transient subclinical hypothyroid
CHD
No. of events/no. at risk	431/1749	51/156	22/91
Incidence (95% CI) per 1000 person-years	32.9 (30.0–36.2)	46.1 (35.1–60.7)	32.1 (21.2–48.8)
HR (95% CI)	1.0	1.37 (1.00–1.87)	1.00 (0.65–1.53)
HF
No. of events/no. at risk	476/2155	42/193	27/117
Incidence (95% CI) per 1000 person-years	29.3 (26.8–32.1)	29.4 (21.7–39.8)	30.5 (20.9–44.4)
HR (95% CI)	1.0	0.89 (0.63–1.25)	1.01 (0.68–1.49)
CV death
No. of events/no. at risk	394/2298	45/206	24/129
Incidence (95% CI) per 1000 person-years	21.4 (19.4–23.6)	27.7 (20.7–37.1)	23.2 (15.5–34.6)
HR (95% CI)	1.0	0.97 (0.64–1.48)	0.99 (0.70–1.39)

Adjusted for age, sex, race, and initiation of thyroid medication during follow-up period.