Table 1.
Baseline Characteristics of the Cohort of Women With IHH Treated With iv GnRH
| Normal IHH | Abnormal IHH |
||
|---|---|---|---|
| Pituitary Resistance | Ovarian Resistance | ||
| n | 22 | 12 | 3 |
| Anosmia, % | 55% | 42% | 0%a,b |
| Age, y | 28.5 ± 7.4 (16.8–41.9) | 30.5 ± 6.9 (17.6–39.4) | 36.0 ± 4.9a (31.2–41.0) |
| BMI, kg/m2, median (IQR) | 22.4 (19.2–25.9) | 28.0 (22.9–36.5)b | 22.8 (22.6–25.9) |
| Partial puberty, % | 46% | 75% | 0% |
| FSH, IU/L | 0.87 (0.24–2.87) | 0.44 (0.22–0.99)b | 0.57 (0.50–0.70)b |
| LH, IU/L | 0.28 (0.09–1.00) | 0.20 (0.08–0.44) | 0.34 (0.23–1.19) |
| Apulsatile baseline study, % | 52% | 83% | 100%b |
| Ovarian volume, mLc | 1.6 (1.4–2.7) | 1.9 (1.0–2.2) | 1.5 (1.1–2.4) |
a
P < .05 vs pituitary resistance.
b
P < .05 vs normal response cycles.
c
Mean ovarian volume in normal spontaneously cycling women is 9.5 mL (95% confidence interval 3.9–15.9 mL) (48).