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. Author manuscript; available in PMC: 2013 Feb 6.
Published in final edited form as: Cells Tissues Organs. 2004;176(1-3):95–108. doi: 10.1159/000075031

Fig. 5.

Fig. 5

Regeneration of a critical size cranial defect with AdCMV-BMP7-transduced fibroblasts [from Krebsbach et al., 2000]. Dermal fibroblasts isolated from Lewis rats were transduced with AdCMV-BMP7 (a) or lacZ control virus (b). Cells were adsorbed to a gelatin sponge and placed in a 9-mm-diameter cranial defect created in a Lewis rat host. Calvariae were isolated for histological analysis after 4 weeks. Black arrows designate the surgical margins. Original magnification: ×25. AdCMV-BMP7-transduced cells were able to repair a calvarial defect while control cells produced only fibrous connective tissue.