Table A1.
Details of Study Regimens
| S Studies |
C Studies |
G Studies |
|||
|---|---|---|---|---|---|
| Protocol | Description | Protocol | Description | Protocol | Description |
| s1a | STLI (stg I/IIA) | c1a | STLI (ps I-IIA) | g1a | ST+Spleen |
| s1b | IF+MOP (stg I/IIA) | c1b | IF + VBM×6 (ps I-IIA) | g1a-K | Kaiser ST+Spleen |
| s2a | STLI+MOP (stg IEA/IIEA) | c2a | STLI (ps I-IIB) | g1b | VBM×2/mantle/VBM×4 |
| s2b | STLI+PAVe (stg IEA/IIEA) | c2b | IF + VBM×6 (ps I-IIB) | g1b-K | Kaiser VBM×2/mantle/VBMx4 |
| s3a | TLI+MOP (stg IEB/IIEB) | c3a | TLI (ps IIIA) | g2 | Stanford V×3, consolidated RT (36 Gy) |
| s3b | TLI+PAVe (stg IEB/IIEB) | c3b | IF + VBM×6 (ps IIIA) | g2b | Stanford V, RT |
| s4a | TLI+MOP (stg IIIA/IIISA) | c4a | PAVe×3/mod IF/PAVe×3 | g3 | Stanford V×3, consolidated RT (36 Gy) |
| s4b | TLI+PAVe (stg IIIA/IIISA) | c4b | ABVD×3/mod IF/ABVD×3 | g4 | Stanford V×8 weeks, RT |
| s5a | MOPP-2+TLI+MOPP-4 (stg IIIB | c5a | PAVe×3/mod IF/PAVe×3 | g4-K | Stanford V×8, RT |
| s5b | PAVe-2+TLI+PAVe-4 (stg IIIB | c5b | ABVD×3/mod IF/ABVD×3 | ||
| s6a | MOPP-2+TLI+MOPP-4 (stg IVL) | c6a | PAVe/mod IF ping-pong | ||
| s6b | PAVe-2+TLI+PAVe-4 (stg IVL) | c6b | ABVD/mod IF ping-pong | ||
| s7a | TLI+MOPP-6 (stg IVH) | c7a | PAVe/TLI ping-pong | ||
| s7b | MOPP-6+IF (stg IVH) | c7b | PAVe/ABVD alt × 12 | ||
| s8a | Split-course (stg IVM) | c8a | PAVe/TLI ping-pong | ||
| s8b | MOPP alone | c8b | PAVe/ABVD alt × 12 | ||
| s8b,b | MOPP, bleomycin | c9a | PAVe/TLI ping-pong | ||
| c9b | PAVe/ABVD alt × 12 | ||||
| c10a | PAVe/TLI ping-pong (stg IV) | ||||
| c10b | PAVe/ABVD alt × 12 (stg IV) | ||||
| c12a | PAVe/TLI ping-pong | ||||
| c12b | MOPP/ABVD | ||||
| c13a | PAVe/TLI ping-pong | ||||
| c13b | MOPP/ABVD | ||||
| c14a | PAVe/TLI ping-pong | ||||
| c14b | MOPP/ABVD | ||||
| c15a | PAVe/TLI | ||||
| c15b | MOPP/ABVD | ||||
Abbreviations: ABVD, doxorubicin, bleomycin, vinblastine, dacarbazine; alt, alternate; IF, involved field; mod, modified; MOP, mechlorethamine, vincristine, procarbazine; MOPP, mechlorethamine, vincristine, procarbazine, prednisone; PAVe, procarbazine, melphalan, vinblastine; RT, radiation therapy; ps, pathologic stage; Stanford V, mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, prednisone; stg, stage; STLI, subtotal lymphoid irradiation; TLI, total lymphoid irradiation; VBM, vinblastine, bleomycin, methotrexate.