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. 2012 Dec 4;2(12):e200. doi: 10.1038/tp.2012.121

Figure 1.

Figure 1

Negative correlation between GM density and serum NSE detected in a set of lean (BMI<25) and overweight and obese (BMI>25) participants, color coded in red/yellow, using a voxel threshold of P<0.005 and a cluster threshold of P<0.05, FDR-corrected. In the group of 27 overweight and obese subjects, we found a significant negative correlation between GM density and serum NSE concentration in the left and right cerebellum (middle row). Such a negative correlation was also detected bilaterally in the medial temporal lobe (see middle row, axial view). For the control group we were not able to show a negative correlation between GM density and NSE levels in the cerebellum (top row). The interaction contrast between both factors of body weight and NSE shows the difference between lean and non-lean subjects with respect to the negative correlation between GM density and NSE (bottom row). In that interaction contrast, both cerebellar clusters remained significant showing the negative correlation between GM density and NSE specific to overweight and obese subjects.