Table 1a. Clinical and serological status according to HERV-W RNA transcriptional level (HERV+ and HERV−).
|
BD |
SZ |
|||||||
|---|---|---|---|---|---|---|---|---|
| N used (±) | HERV+ (N=51) | HERV− (N=40) | P-value | N used (±) | HERV+ (N=17) | HERV−(N=28) | P-value | |
| Age at onset (years±s.d. ) | 48/39 | 25.83 (8.6) | 27.28 (11.6) | 0.931 | 16/26 | 24.06 (10) | 23.65 (5.8) | 0.773 |
| Age at interview (years±s.d.) | 49/40 | 44.55 (12) | 42.9 (13.2) | 0.723 | 16/25 | 33.93 (11.1) | 35.28 (11.3) | 0.749 |
| Duration of illness (years±s.d.) | 49/39 | 18.30 (11.9) | 15.17 (10.1) | 0.220 | 16/25 | 9.88 (6.4) | 11.6 (10.5) | 0.952 |
| Number of episodes | 43/39 | 8.62 (6.3) | 8.33 (7.8) | 0.270 | 15/24 | 4.10 (3.1) | 4.12 (3) | 0.898 |
| MADRS (mean scores) | 49/40 | 6.18 (9.1) | 6.98 (8.9) | 0.792 | ||||
| YMRS (mean scores) | 49/39 | 4.50 (7.1) | 5.43 (7.8) | 0.727 | ||||
| PANSS (mean total scores) | 45/35 | 37.13 (11.5) | 38.94 (13.3) | 0.896 | 15/20 | 65.93 (20.9) | 65.1 (15.1) | 0.469 |
Abbreviations: BD, (patients with) bipolar disorder; HERV-W, Human Endogenous Retrovirus type-W; MADRS, Montgomery and Asberg Depression Rating Scale; PANSS, Positive And Negative Syndrome Scale; SZ, (patients with) schizophrenia;YMRS, Young Mania Rating Scale.
HERV-W expression status among patients with BD and SZ.
HERV-W ‘Positives' have a transcriptional level with RNA copy number significantly elevated, compared with background transcription in healthy controls; ‘Negatives' have RNA copy number below the threshold (see Patients and methods).
As few samples could not be tested for all parameters (insufficient volume, quality control not passed, and so on) the numbers effectively tested and used for calculations presented in Table 1a are indicated in columns with ‘N used (±)'.