Figure 3.

The similar fatty acid (FA) metabolic abnormalities in affective disorder brains and rat hippocampi chronically treated with antidepressants. (a) 22:5n-3 in the inferior temporal cortex (ITC). In contrast to the frontopolar cortex (FPC) (Figure 2a), the concentration of 22:5n-3 decreased significantly in the affective disorder ITC. (b) 22:5n-3 in the rat hippocampus chronically treated with or without antidepressants. Chronic antidepressant treatment significantly reduced the concentrations of 22:5n-3 in the rat hippocampus. (c, d) 20:1n-9/18:1n-9 ratios in the FPC and rat hippocampus. As the myelin fibers (MFs) (myelin proportions in the cortical homogenates) increased, these ratios increased and became abnormally upregulated in the affective disorder FPC (c), as well as in the rat hippocampus chronically treated with antidepressants (d).