Table 1. Demographic data of eight PD samples included in the final meta-analysis.
| Sample |
Number |
Gender |
PD diagnosis | Comorbidity | ||
|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Cases | |
| ACG total | 460 | 856 | ||||
| Aarhus | 102 | 511 | Male 25.0% | Male 50.5% | PDA 56%, PD 44% | MDE 22.2% |
| Copenhagen | 141 | 345 | Female 75.0% | Female 49.5% | PPD 77.6% | SA 5.2% |
| Gothenburg | 217 | 0 | NS 47.1% | |||
| Tartu | 217 | 285 | Male 23.0% | Male 30.0% | PDA 61.5%, PD 38.5% | MDE/BP 62.3% |
| Female 77.0% | Female 70.0% | PPD 49.7 | SA 15.6% | |||
| IT total | 165 | 163 | ||||
| Iowa | 38 | 40 | Male 29.7% | Male 26% | PDA 75.6%, PD 24.4% | MDE/BP 39.9% |
| Toronto | 127 | 123 | Female 70.3% | Female 74% | PPD 60.6% | |
| NIMH | 77 | 192 | Male 21.0% | Male 21.0% | PDA 38.8%, PD 61.2% | MDE/BP 100% |
| Female 79.0% | Female 79.0% | PPD 0% | ||||
| Japan | 760 | 770 | Male 31.8% | Male 52.8% | PDA 57.3%, PD 42.7% | MDE 42.8%, SA 5.2%, OAD 4.0%, OCD 3.3% |
| Female 68.2% | Female 47.2% | PPD 35.8% | ||||
| MPIa | 216 | 222 | Male 33.2% | Male 32.9% | PDA 83.3%, PD | — |
| Female 66.8% | Female 67.1% | 16.7% PPD 100% | ||||
| PD German multicentera | 225 | 240 | Male 40.4% | Male 40.2% | PDA 67.5%, PD | MDE 22.7% |
| Female 59.6% | Female 59.8% | 32.5% PPD 78.2% | SA 8.9%, NS 25.3% | |||
| Bonna | 436 | 452 | Male 33.3% | Male 50.9% | PDA 39%, PD 20.4% | MDE/BP 73.4%, OAD 40.6% |
| Female 66.7% | Female 49.1% | PPD 10.1% | SchiD 10.6% | |||
Abbreviations: ACG, Aarhus, Copenhagen (Denmark), Gothenburg (Sweden); BP, bipolar disorder; IT, Iowa, Toronto (USA, Canada); MDE, depressive disorder; MPI, Max Planck Institute for Psychiatry, Munich; NIMH, National Institute for Mental Health (USA); NS, not specified; OAD, other anxiety disorders; PDA, panic disorder with agoraphobia; PD, panic disorder without agoraphobia; PD German multicenter, recruited in Münster, Würzburg, Göttingen and Bonn; PPD, primary PD, exclusion of severe and recurrent major depression, bipolar disorder, schizophrenia and substance dependence; SA, substance abuse or dependence secondary to the panic disorder (mainly alcoholism); SchiD, schizophrenic disorder.
Patients and controls were matched by age; mean age of all patients 39.1 (s.d. 11.5); mean age controls 39.4 (s.d. 11.9).
PD samples previously genotyped in Erhardt et al.