Table 2. Single-SNP association analysis, haplotype analysis and meta-analysis results of the five newly genotyped samples from the PanIC.

Samples	ACG	Tartu	IT	NIMH	Japan	Combined
Number of cases	460	217	165	77	760	1679
Number of controls	856	285	163	192	770	2266
SNPs
rs7309727
P-value	0.001	0.5	0.7	0.05	0.4	0.41
OR (CI)	1.36 (1.13–1.65)	1.09 (0.82–1.47)	0.95 (0.66–1.36)	0.63 (0.39–1.0)	0.94 (0.81–1.09)	1.04 (0.93–1.16)
rs11060369
P-value	0.9	0.6	0.01	0.6	0.8	0.28
OR (CI)	0.99 (0.83–1.18)	0.92 (0.7–1.21)	0.67 (0.49–0.94)	0.90 (0.61–1.32)	0.98 (0.85–1.14)	0.94 (0.87–1.04)
rs9804847
P-value	0.9	0.3	0.05	0.17	0.2	0.97
OR (CI)	1.0 (0.85–1.18)	1.15 (0.88–1.49)	0.72 (0.52–1.01)	0.77 (0.53–1.11)	1.21 (0.93–1.58)	0.99 (0.89–1.11)
rs4759958
P-value	0.07	0.8	0.1	0.7	0.3	0.036
OR (CI)	1.17 (0.98–1.38)	0.96 (0.73–1.28)	0.28 (0.93–1.75)	1.07 (0.73–1.60	1.07 (0.93–1.24)	1.11 (1.0–1.23)
Haplotype rs7309727–rs11060369
Omnibus test	0.0054	0.81	0.21	0.037	0.33	0.47
CC
P-value	0.69	0.54	0.02	0.51	0.82	0.77
OR (CI)	0.98 (0.82–1.17)	0.92 (0.70–1.21)	0.67 (0.49–0.94)	0.99 (0.82–1.17)	0.98 (0.81–1.1)	0.99 (0.90–1.08)
TA
P-value	0.0023	0.5	0.7	0.057	0.37	0.036
OR (CI)	1.36 (1.12–1.65)	1.1 (0.81–1.49)	0.95 (0.66–0.37)	0.63 (0.4–1.0)	0.93 (0.81–1.08)	1.11 (0.10–1.24)
CA
P-value	0.006	0.9	0.01	0.017	0.16	0.064
OR (CI)	0.79 (0.67–0.93)	1.0 (0.99–1.01)	1.5 (1.1–2.05)	1.6 (1.1–2.39)	1.15 (0.95–1.39)	0.91 (0.84–1.0)

Abbreviations: ACG, Aarhus, Copenhagen, Gothenburg; CI, 95% confidence interval; EA, European ancestry,all samples except the Japanese sample; IT, Iowa, Toronto (USA, Canada); NIMH, National Institute for Mental Health (USA); OR, odds ratio; PanIC, Panic Disorder International Consortium; SNP, single-nucleotide polymorphism.

Nominally significant P-values are displayed in bold digits.