Table 3. Meta-analysis results for eight PD samples (PanIC: n=5; Erhardt et al.: n=3) for the top SNPs and the best associated haplotype rs7309727–rs11060369 in the TMEM132D gene.
| Samples | Combined | European ancestry | European ancestry PPD | Japan PPD |
|---|---|---|---|---|
| Number of cases | 2678 | 1863 | 1038 | 760 |
| Number of controls | 3262 | 2411 | 2411 | 770 |
| SNPs | ||||
| rs7309727 | ||||
| P-value | 0.0007 | 3.98e−6 | 1.05e−8 | 0.27 |
| OR (CI) | 1.16 (1.05–1.26) | 1.27 (1.15–1.41) | 1.45 (1.20–1.72) | 0.90 (0.73–1.09) |
| p-het | 5.97e−6 | 0.0003 | NS | |
| rs11060369 | ||||
| P-value | 0.0007 | 7.64e−5 | 0.0004 | 0.78 |
| OR (CI) | 0.87 (0.74–0.94) | 0.83 (0.75–0.90) | 0.81 (0.73–0.89) | 0.97 (0.80–1.18) |
| p-het | 0.01 | 0.034 | NS | |
| rs9804847 | ||||
| P-value | 0.05 | 0.1 | 0.12 | 0.16 |
| OR (CI) | 1.08 (1.0–1.18) | 1.07 (0.98–1.17) | 1.09 (0.96–1.22) | 1.29 (0.90–1.84) |
| p-het | 0.009 | 0.006 | 0.005 | |
| rs4759958 | ||||
| P-value | 0.003 | 0.006 | 0.06 | 0.08 |
| OR (CI) | 1.12 (1.1–1.21) | 1.14 (1.05–1.26) | 1.11 (0.97–1.26) | 1.20 (0.98–1.47) |
| p-het | NS | NS | NS | |
| Haplotype rs7309727–rs11060369 | ||||
| Omnibus test | 0.00014 | 1.12e−6 | 5.02e−8 | 0.13 |
| CC | ||||
| P-value | 0.0003 | 3.8e−5 | 0.0004 | 0.73 |
| OR (CI) | 0.87 (0.8–0.93) | 0.82 (0.75–0.90) | 0.80 (0.73–0.89) | 0.96 (0.80–1.17) |
| p-het | 0.02 | 0.022 | NS | |
| TA | ||||
| P-value | 0.001 | 3.35e−6 | 1.4e−8 | 0.24 |
| OR (CI) | 1.15 (1.06–1.25) | 1.28 (1.15–1.41) | 1.44 (1.20–1.73) | 0.89 (0.74–1.06) |
| p-het | 9.4e−6 | 0.0002 | NS | |
| CA | ||||
| P-value | 0.9 | 0.9 | 0.09 | 0.17 |
| OR (CI) | 1.0 (0.99–1.01) | 1.0 (0.99–1.01) | 0.91 (0.82–1.0) | 1.3 (0.92–1.83) |
| p-het | 9.6e−4 | 0.001 | NS | |
Abbreviations: ACG. Aarhus, Copenhagen, Gothenburg; CI, 95% confidence interval; Combined, all eight PD samples including the initial German samples from Munich, PD German multicenter and Bonn; European ancestry, all samples except the Japanese sample; IT, Iowa, Toronto (USA, Canada); NIMH, National Institute for Mental Health (USA); NS, not significant; OR, odds ratio; p-het, P-value test for heterogeneity; PanIC, Panic Disorder International Consortium; PPD, primary panic disorder, exclusion of cases with severe and recurrent major depression, bipolar disorders, schizophrenia and substance dependence; SNP, single-nucleotide polymorphism.
Results for the combined meta-analysis and subsamples. P-values surviving correction for multiple testing genome-wide are displayed in bold.