Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Sep 11;2(9):e159. doi: 10.1038/tp.2012.86

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

PMC Copyright notice

Increased 5-hydroxymethylcytosine (5hmC) at the glutamic acid decarboxylase 67 (GAD67) promoter in psychotic (PSY) patients. Binding of 5-methylcytosine (5mC) (a) and 5hmC (b) to GAD67 promoter was measured by immunoprecipitation using specific 5hmC and 5mC antibodies with previously published procedures.⁴ We find significantly increased 5hmC, but not 5mC, in PSY patients () compared with nonpsychiatric (CTR) subjects (□) at both regions of the GAD67 promoter examined. *P<0.05 vs CTR; **P<0.01 vs CTR.

Inline graphic — Increased 5-hydroxymethylcytosine (5hmC) at the glutamic acid decarboxylase 67 (GAD67) promoter in psychotic (PSY) patients. Binding of 5-methylcytosine (5mC) (a) and 5hmC (b) to GAD67 promoter was measured by immunoprecipitation using specific 5hmC and 5mC antibodies with previously published procedures.⁴ We find significantly increased 5hmC, but not 5mC, in PSY patients () compared with nonpsychiatric (CTR) subjects (□) at both regions of the GAD67 promoter examined. *P<0.05 vs CTR; **P<0.01 vs CTR.