Table 3. Increased 5hmC at GAD67 and BDNF promoters in psychotic patients.
| Gene (position relative to TSS) | 5mC | 5hmC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
CTR |
PSY |
t-Value |
d.f. |
P-Value |
CTR |
PSY |
t-Value |
d.f. |
P-value |
| GAD67 (−537 to −415) | 0.71±0.24 | 1.13±0.37 | 0.799 | 39 | NS | 0.62±0.16 | 2.45±0.90 | 2.004 | 39 | 0.05 |
| GAD67 (−145 to +21) | 0.90±0.33 | 1.48±0.49 | 0.819 | 39 | NS | 0.39±0.12 | 2.87±0.89 | 2.801 | 39 | 0.009 |
| BDNF IXabcd (−60 to +50) | 1.99±0.68 | 9.42±2.26 | 3.14 | 39 | 0.005 | 2.32±0.81 | 9.86±2.50 | 2.873 | 39 | 0.008 |
| BDNF IXabcd (+1185 to +1305) | 8.83±2.65 | 10.78±2.49 | 0.499 | 39 | NS | 11.10±2.58 | 12.85±2.59 | 0.438 | 39 | NS |
Abbreviations: APOBEC, apolipoprotein B mRNA-editing enzyme; BDNF, brain-derived neurotrophic factor; CTR, nonpsychiatric; DEP, depressed; d.f., degree of freedom; GAD67, glutamic acid decarboxylase67; 5hmC, 5-hydroxymethylcytosine; 5-methyl cytosine; IPL, inferior parietal lobule; NS, nonsignificant; PSY, psychotic; TSS, transcriptional star site.